University of California, Irvine

The MODEL-AD consortium consisting of a Center at Indiana University, The Jackson Laboratory, and Sage Bionetworks and a Center at the University of California Irvine has been established by the National Institute on Aging to:

Develop the next generation of in vivo AD models based on human data
Institute a standardized and rigorous process for characterization of animal models
Align the pathophysiological features of AD models with corresponding stages of clinical disease using translatable biomarkers
Establish guidelines for rigorous preclinical testing in animal models
Ensure rapid availability of animal models, protocols and validation data to all researchers for preclinical drug development